Capacity building and policy development in Belize marine protected areas, an example for Caribbean integrated coastal management / Desarrollo de capacidades y desarrollo de políticas en áreas marinas protegidas de Belice, un ejemplo para la gestión integrada de la costa del Caribe

Sustainability science can, through capacity building, allow for integrated stakeholder management of the vital Caribbean marine ecosystems. We did a capacity building exercise in two major coral reef areas in Southern Belize. The key outcome was a six-month personal/professional action plan developed by each participant about tactics for leading, educating and supporting issues regarding sustainable development and tactics for collaboration to influence policy decisions. Our results can be applied across the Caribbean. Rev. Biol. Trop. 62 (Suppl. 3): 287-291. Epub 2014 September 01.

La ciencia de la sostenibilidad puede, a través del desarrollo de capacidades, permitir la gestión integrada de los actores interesados en estos ecosistemas marinos vitales del Caribe. Realizamos un ejercicio de desarrollo de capacidades en dos importantes arrecifes de coral al sur de Belice. El resultado clave fue el desarrollo de un plan de acción personal/profesional de seis meses para cada participante sobre técnicas para liderar, educar y apoyar los problemas acerca del desarrollo sostenible y técnicas para influir en decisiones políticas. Nuestros resultados se pueden ejecutar a lo largo de todo el Caribe.

Small heat shock proteins (sHSPs) as potential drug targets.

Small heat shock proteins (sHSPs) belong to a family of 12- to 43-kDa proteins that are ubiquitous and are largely conserved in amino acid sequence among all organisms. The principal heat-shock proteins that have chaperone activity (that is, they protect newly made proteins from misfolding) belong to five conserved classes: HSP100, HSP90, HSP70, HSP60 and the small heat-shock proteins (sHSPs). The sHSPs (which include alpha crystallin) can form large multimeric structures and have a wide range of cellular functions, including endowing cells with thermotolerance in vivo and being able to act as molecular chaperones in vitro; sHSPs do this by forming stable complexes with folding -or unfolding--intermediates of their protein substrates, probably the molten globule. This paper includes: a brief survey of the chaperone family, the small heat shock protein superfamily, transcription of sHSPs, sequence comparisons and structural models of small heat shock proteins--structural elements as potential drug targets, sHSPs as chaperone-like proteins, alpha crystallin chaperone-like activity, conformational diseases--the role of alpha crystallin small heat shock protein superfamily proteins, post-translational modification and useful pharmacological agents. Functionality of small heat shock proteins--targets and diseases where pharmacologically active agents are of importance, alpha crystallin--small heat shock proteins and prion diseases: specific targets for diagnostic tests and drug development, details of some specific small heat shock proteins as drug targets, structural and functional implications for treatment.

Chemical modification studies on purified bovine lens aldose reductase.

Chemical modification studies on homogeneous bovine lens aldose reductase using diethylpyrocarbonate, phenylglyoxal, butanedione, N-ethylmaleimide and p-chloromercuribenzoate indicate that histidine and arginine residues located at or near the nucleotide binding site may be important in binding or orientation of the NADPH, and that NADPH oxidation with glucose requires protein thiol.